16 Best Five-Star Hotels in the US for a Long Weekend Getaway

7. The Sanctuary at Kiawah Island Golf Resort - South Carolina's Coastal Haven

Set on one of America's most pristine barrier islands, The Sanctuary at Kiawah Island Golf Resort offers a long weekend escape that perfectly balances luxury accommodation with access to some of the country's most beautiful natural environments. This oceanfront resort, with its distinctive architecture inspired by the grand seaside hotels of the early 20th century, features 255 rooms and suites that showcase stunning views of the Atlantic Ocean or the resort's championship golf courses. The property's design celebrates the Lowcountry's rich cultural heritage while incorporating modern amenities and sustainable practices that protect the island's delicate ecosystem. Guests can choose from five championship golf courses, including the famous Ocean Course that has hosted major championships and offers dramatic holes that play along the Atlantic coastline. The resort's spa provides a tranquil retreat with treatments that incorporate indigenous ingredients like sweetgrass and sea salt, reflecting the healing traditions of the Lowcountry. During a long weekend, visitors can explore the island's 10 miles of pristine beaches, participate in guided nature tours that showcase the area's incredible biodiversity, or simply relax by the resort's stunning infinity pool that seems to merge with the ocean horizon. The dining options celebrate the rich culinary traditions of the South Carolina coast, featuring fresh seafood, locally grown produce, and traditional Lowcountry preparations that have been passed down through generations. The resort's commitment to environmental stewardship ensures that this natural paradise will remain unspoiled for future generations to enjoy.