12 Best Road Trip Routes in the US — With Estimated Costs

4. Great River Road (Minnesota to Louisiana) - $2,500-$3,800 for 14 Days

The Great River Road follows the mighty Mississippi River for 3,000 miles through ten states from its humble beginnings at Lake Itasca in Minnesota to its dramatic delta in Louisiana, offering an unparalleled journey through the geographic and cultural heart of America. This National Scenic Byway showcases the diverse landscapes, rich history, and vibrant cultures that have developed along North America's greatest river system, from the pristine wilderness of northern Minnesota through the agricultural heartland of Iowa and Illinois, the musical heritage of Memphis and the Mississippi Delta, to the unique Creole and Cajun cultures of Louisiana. The journey typically requires 12-16 days to experience fully, allowing time to explore major cities like Minneapolis, St. Louis, Memphis, and New Orleans, while also discovering charming river towns, historic sites, and natural areas that tell the story of American expansion, commerce, and cultural development. Budget planning for the Great River Road varies significantly by region, with fuel costs averaging $450-650 for the complete route, accommodation ranging from $70-200 per night depending on location and season, with premium rates in New Orleans and during peak travel periods, and dining expenses of $35-60 per day featuring regional specialties from Midwest comfort food to Southern barbecue and Creole cuisine. Attraction costs include major sites like the Gateway Arch ($15), Graceland ($40-75), and various river museums and historic homes ($8-20), while entertainment expenses in music cities like Memphis and New Orleans can add $30-100 per evening for live performances and cultural experiences. The total estimated cost ranges from $2,500-3,800 for two people, providing excellent value for a comprehensive exploration of American river culture and the diverse regions that define the nation's heartland.