12 Best Road Trip Routes in the US — With Estimated Costs

2. Route 66 - The Mother Road - $2,200-$3,500 for 12 Days

Route 66, immortalized as "The Mother Road" by John Steinbeck, remains America's most legendary highway despite its official decommissioning in 1985, offering a nostalgic journey through the heart of American culture and history across 2,448 miles from Chicago to Santa Monica. This historic route passes through eight states—Illinois, Missouri, Kansas, Oklahoma, Texas, New Mexico, Arizona, and California—showcasing an incredible diversity of landscapes from Midwest farmlands to Southwestern deserts, while preserving countless vintage motels, diners, and roadside attractions that harken back to the golden age of automobile travel. The journey typically requires 12-15 days to experience fully, allowing time to explore iconic stops including the Gateway Arch in St. Louis, Cadillac Ranch in Amarillo, the Petrified Forest in Arizona, and the Grand Canyon's South Rim. Budget planning for Route 66 benefits from generally lower costs compared to coastal routes, with fuel expenses averaging $350-500 for the complete journey, accommodation ranging from $60-150 per night at historic motor lodges and budget chains, and dining costs of $25-45 per day featuring classic American comfort food at legendary establishments like Lou Mitchell's in Chicago and The Big Texan in Amarillo. Attraction costs remain modest, with most roadside attractions charging $5-15 admission, while major sites like the Grand Canyon require $35 for a seven-day vehicle pass. The total estimated cost ranges from $2,200-3,500 for two people, making it an affordable way to experience America's automotive heritage while traversing some of the country's most historically significant and culturally rich regions.