62 Universities Located in America's Most Underrated Cities

24. Case Western Reserve University (Cleveland, OH): Research Muscle in the Midwest

Situated in Cleveland's University Circle cultural hub, Case Western Reserve is a powerhouse private research university. Its strengths lie in engineering, nursing, law, and particularly medicine, thanks to deep partnerships with the world-famous Cleveland Clinic and University Hospitals. While Cleveland works to redefine its image beyond its industrial past, CWRU offers students top-tier academics, extensive research funding, and access to world-class cultural institutions (like the Cleveland Museum of Art) often at a value compared to coastal peers.